Although the exact biological functions of laforin remain unclear, its functions in glycogen regulation, protecting cells from ER stress conditions, suppressing cytotoxicity production, autophagy regulation and tumor suppression have been proposed (Worby et al., 2006; Garyali et al., 2009; Vernia et al., 2009; Gentry et al., 2013). The gene discussed is EPM2A; the disease is neoplasm.