In addition, studies in sarcopenia found that RANKL activated NF-kB signaling to induce insulin resistance in muscle cells in response to TNF-a, and recombinant human osteoprotegerin (OPG-Fc) reversed the resistance, increased glucose uptake in muscle cells, and downregulated the expression of inflammatory and anti-myogenic genes. This evidence concerns the gene TNFRSF11B and Insulin resistance.