Previous reports demonstrated that LF specifically upregulates TP53 gene expression in HeLa cells through the activation of NF-κB, resulting in activation of p53 downstream signal (Oh et al., 2004), but bLF also induces the phosphorylation of p53 and induces p21 in cancer cells (Chea et al., 2018a). The gene discussed is NFKB1; the disease is cancer.