HPRT1 and acute myeloid leukemia: Noteworthy, the enzyme HGPRT, which catalyzes the conversion of hypoxanthine or guanine and 5-phospho-α-D-ribose 1-diphosphate (PRPP) to, respectively, inosine 5′-monophosphate (IMP) or GMP and pyrophosphate (PPi), has recently been demonstrated to be crucial in other tumoral cells such as those involved in acute myeloid leukemia (Wang et al., 2022).