As shown in Figures 3(b) and 3(c) and Supplementary Figure 1A, B, overexpression of CHIP inhibited the expression of stemness-related transcription factors (Oct4, SOX2, and Nanog) and sphere formation capacity in CD133+ cells, suggesting that CHIP could inhibit the self-renewal ability of NSCLC stem cells. The gene discussed is POU5F1; the disease is non-small cell lung carcinoma.