Presence of the TNFAIP3 SLE risk haplotype in EBV B cells significantly increased the interaction frequency between this enhancer and three primers (U3, U4, U5) in the regulatory elements near IL20RA and IFNGR1, as well as one primer in the second intron of TNFAIP3 (D7) (Figure 3B). This evidence concerns the gene IFNGR1 and systemic lupus erythematosus.