TNFAIP3 and systemic lupus erythematosus: Spanning this TAD are 15 disease-associated haplotypes from European or East Asian ancestry, including the ∼109 kb SLE risk haplotype correlated with reduced TNFAIP3 gene expression in SLE patient populations of European and Korean ancestry (Graham et al., 2008; Adrianto et al., 2011; Ray et al., 2020).