Functional dissection of this enhancer demonstrated that it forms long-range contacts with several regulatory regions, including an interaction with the upstream promoter regions of IL20RA and IFNGR1. The long-range interaction between this enhancer and IL20RA and IFNGR1 in Epstein-Barr virus (EBV) transformed B (EBV B) cells from donors carrying the TNFAIP3 SLE risk haplotype tagged by rs10499197 exhibited increased interaction frequency, as well as increased IL20RA and IFNGR1 expression, suggesting the risk haplotype may influence gene expression beyond TNFAIP3. This evidence concerns the gene IL20RA and systemic lupus erythematosus.