As for the impact of this enhancer on hypomorphic TNFAIP3 expression, our demonstrations of the enhancer looping to promoter/enhancer elements within the TNFAIP3 gene body and the allele-specific loss of RelA/p65 binding could support a role in TNFAIP3 suppression, which is characteristic of other variants carried on the SLE risk haplotype (Adrianto et al., 2011; Wang et al., 2013; Wang et al., 2016; Sokhi et al., 2018; Ray et al., 2020). Here, TNFAIP3 is linked to systemic lupus erythematosus.