Together, the two binding motifs increase risk allele-specific expression of IL20RA and IFNGR1. While other independent risk haplotypes have been associated with long-range looping and allele-specific modulation of IL20RA and IFNGR1 gene expression (McGovern et al., 2016), our results are the first to show participation of the ∼109 kb SLE risk haplotype in this activity. Here, IL20RA is linked to systemic lupus erythematosus.