Since the SLE risk haplotype has been shown to suppress TNFAIP3 expression, we expected the enhancer element tagged by rs10499197 to exert its function similarly as we previously described for the TT>A enhancer element (Adrianto et al., 2011; Wang et al., 2013; Wang et al., 2016). The gene discussed is TNFAIP3; the disease is systemic lupus erythematosus.