In EBV B cells carrying the TNFAIP3 SLE non-risk or risk haplotype, we observed strong interactions between this enhancer and regulatory elements near IL20RA and IFNGR1, as well as the promoter region and enhancer elements in the first and second introns of TNFAIP3 (Figure 3B). This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.