TNFAIP3 and systemic lupus erythematosus: Although this enhancer is included in several autoimmune disease haplotypes spanning the TNFAIP3 locus, including the SLE risk haplotype studied herein, and has common SNPs, rs10499197 and rs58905141, shown to alter chromatin dynamics and enhancer activity, the functional significance and allelic effects on gene expression has remained unclear.