By leveraging patient-derived EBV B cell lines that were homozygous for either the non-risk or risk TNFAIP3 SLE risk haplotype tagged by rs10499197, we uncovered a complex chromatin regulatory network that spans ∼1M bp from the promoter region of IL20RA to the 3’ untranslated region of TNFAIP3 (Adrianto et al., 2011; Wang et al., 2013; Wang et al., 2016). The gene discussed is TNFAIP3; the disease is systemic lupus erythematosus.