Our data from EBV B cell lines that carry the risk allele of rs9494868 but do not carry the SLE risk haplotype suggest that, for the hypermorphic expression of the IL20RA and IFNGR1, increased looping to the enhancer regions flanking these genes is required along with increased enhancer activity promoted by the SLE risk alleles. Here, IFNGR1 is linked to systemic lupus erythematosus.