Several SNPs carried on this SLE risk haplotype are non-protein-coding SNPs shared by other TNFAIP3 haplotypes and positioned in predicted enhancer elements based on chromatin accessibility, histone marks of active enhancers, and enrichment of transcription factor binding sites (Sokhi et al., 2018; Ray et al., 2020). This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.