Therefore, we performed 3C-qPCR using EBV B cells that were homozygous for the TNFAIP3 SLE non-risk haplotype with or without the risk allele of rs9494868 to determine if rs9494868 influenced the haplotype-specific changes in the observed chromatin-chromatin interactions at this locus. This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.