The abnormal control of posttranslational modification-related enzymes, including histone methylase, demethylase, acetylase, and acetyltransferase, acts as a pivotal risk factor for tumors, and these epigenetic alterations may lead to the reprogramming of genomes, activation of oncogenes, or silencing of tumor suppressors (Berry and Janknecht, 2013). Here, MBD2 is linked to neoplasm.