HS3ST3A1 expression is higher in lung cancer compared to normal tissue (Nakano et al., 2012), however, in HER2+ patients with breast cancer, high levels of HS3ST3A expression are associated with reduced recurrence-free survival (Mao et al., 2016); AQP9 encodes the aquaporin 9, which is involved in processes related to cell migration, angiogenesis, and tumor growth (Nico and Ribatti, 2011). This evidence concerns the gene HS3ST3A1 and neoplasm.