We screened the top 30 differential genes from mRNAseq of 10 cases (5 primary LG NMIBC and 5 recurrent HG MIBC), and the gene set enrichment analysis (GSEA) results revealed that Epithelial-Mesenchymal Transition (EMT)" and “Inflammatory Response” were up-regulated in recurrent BC, while “Myc target v2′′ and “P53 pathways " were down-regulated in recurrent BC. This evidence concerns the gene MYC and breast cancer.