To further clarify relevant molecular mechanisms of metformin with PD-L1 MAb in treating NSCLC, we detected levels of p-AMPK and mTOR in CD8+ T cells and set up an AMPK inhibitor addition group (Compound C) to study whether metformin combined with PD-L1 MAb against NSCLC is dependent on the AMPK pathway. Here, MTOR is linked to non-small cell lung carcinoma.