We also observed that intracellular ROS was significantly decreased in sericite-treated mouse neoplasms (Figure 4(e)), along with reduced phosphorylation of p66shc (Figure 4(f)) and reduced mRNA expression of p22phox (Figure 4(g)) and NOX4 (Figure 4(h)), which are upstream regulators of p66shc. Here, NOX4 is linked to neoplasm.