CASP1 and pancreatic ductal adenocarcinoma: For example, in pancreatic ductal adenocarcinoma (PDA) and head and neck squamous cell carcinoma (HNSCC), inflammasomes of tumor-associated macrophages activate caspase-1 and mediate the cleavage of GSDMD and the release of mature IL1β, resulting in the suppression of CD8+ T cells [13, 14].