According to the results of multivariate Cox regression analysis, we constructed a prognostic risk score model for calculating HCC risk as follows: risk score of HCC (RS_HCC) = (−0.1393 × expression value of ADH4) + (0.2214 × expression value of ADH6) + (−0.1339 × expression value of CYP2C9) + (0.1017 × expression value of CYP4F2) + (−0.0978 × expression value of RDH16), with AIC value =1304.0967. The gene discussed is RDH16; the disease is hepatocellular carcinoma.