In our research, we identified 15 major hub genes (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) in the PPI network, and all of them were downregulated genes in sepsis. This evidence concerns the gene IL2RB and Sepsis.