In our research, we identified 15 major hub genes (CCL5, CCR7, CD2, CD27, CD274, CD3D, GNLY, GZMA, GZMH, GZMK, IL2RB, IL7R, ITK, KLRB1, and PRF1) in the PPI network, and all of them were downregulated genes in sepsis. The gene discussed is GZMH; the disease is Sepsis.