NLRP3 and Parkinson disease: Unlike previous studies, which mostly demonstrated the role of NLRP3 in PD pathogenesis by using NLRP3 knockout mice or inhibitors (Guo et al., 2017; Lee et al., 2019; Ou et al., 2021), our study clarified region‐specific effects of NLRP3 on PD pathology that provides straightforward evidence for the association between NLRP3 and PD, and demonstrated the feasibility of disease‐modifying therapy in PD mouse model.