As we known, neuronal pyroptosis and neuroinflammation mediated by NLRP3 inflammasome play an important role in neurodegenerative diseases, which are important regulators of microglial neuroinflammation (Ahmed et al., 2021; Gordon et al., 2018; Haque et al., 2020; Li et al., 2021; Ramesh et al., 2013), we next sought to explore the effects of microglial NLRP3 on DA neurodegeneration. Here, NLRP3 is linked to neurodegenerative disease.