Since extensive NLRP3 inflammasome was found in the SNc of PD patients (Gordon et al., 2018), plentiful studies have focused on exploring the pathophysiological mechanism within NLRP3 and developing treatments targeting NLRP3 inflammasome activation in PD (Qiao et al., 2018; Wang et al., 2020). The gene discussed is NLRP3; the disease is Parkinson disease.