To elucidate the origin of heterogeneity in PCa and its association with disease progression, ERG(+), SPOP, EZH2, SPINK‐1, and NKX3.1 subtypes were analyzed in 103 samples from prostatic foci and regional metastasis to lymph nodes (LN) from 20 PCa patients with poor prognosis. Here, EZH2 is linked to posterior cortical atrophy.