A lower expression in LN samples with respect to all the other groups (LN vs. HGPIN, p = 0.0015; LN vs. GL3, p < 0.001, LN vs. GL4, p < 0.001; LN vs. GL5, p = 0.0236), and between GL5 compared to GL4 samples (p = .0071), indicates that there is an inversely proportional association between PCa progression (HGPIN, GL3, GL4 vs. GL5, LN) and the expression levels of NKX3.1 (Figure 4). The gene discussed is NKX3-1; the disease is posterior cortical atrophy.