In this study, five molecular subtypes associated with PCa were analyzed: ERG(+), EZH2, NKX3.1, SPINK‐1, and SPOP mutation, to establish their association with different lesion degrees and regional metastasis in LN in 20 PCa patients with poor prognosis, as well as the clonal origin of the foci in these patients. Here, SPOP is linked to posterior cortical atrophy.