To elucidate the origin of heterogeneity in PCa and its association with disease progression, ERG(+), SPOP, EZH2, SPINK‐1, and NKX3.1 subtypes were analyzed in 103 samples from prostatic foci and regional metastasis to lymph nodes (LN) from 20 PCa patients with poor prognosis. The gene discussed is NKX3-1; the disease is posterior cortical atrophy.