In this present study, we aimed to establish a prognostic model on the basis of pyroptosis-related genes to  predict the prognosis of patients with PAAD. In addition, we verified the function of GSDMC in PANC-1  and CFPAC-1 cells, which might be a promising therapeutic target for the treatment of PAAD. Our study systematically explored the prognostic value of pyroptosis-related genes and their correlations with clinical characteristics, thus shedding light on the promising roles of pyroptosis-related genes as potential prognostic biomarkers and novel therapeutic targets for PAAD patients. This evidence concerns the gene GSDMC and pancreatic adenocarcinoma.