Furthermore, both PRMT5 knockdown and FKA treatment could induce apoptosis in BC cells; however, using the same FKA concentration, its effect was abated in the high PRMT5 expression group, indicating a dose-dependent relationship between the effect of FKA and PRMT5 expression (Fig. 3g and Supplement Figure S3a, b). The gene discussed is PRMT5; the disease is breast cancer.