POU5F1B and Familial prostate cancer: In addition, we replicated associations between missense risk variant rs6998061 (8q24 locus, POU5F1B) and multiple tumor types in both our prostate cancer-specific analysis [32] (OR [95% CI] = 1.23 [1.13, 1.33], p = 4.39 × 10−7) and our colorectal cancer-specific analysis [33] (OR [95% CI] = 1.25 [1.15, 1.37], p = 1.06 × 10−7).