Compelling findings from our analyses of all individuals with more than one cancer diagnosis include associations with the rare variant rs146381257 in ZNF106. Carriers of the rs146381257 risk allele (C) were primarily overrepresented in individuals with at least one prostate, breast, lung, or urinary bladder cancer and in individuals with lymphoid neoplasms. This evidence concerns the gene ZNF106 and lymphoid neoplasm.