Two of these variants were positively associated in our analysis of any 2+ primary cancers: rs555607708 (CHEK2; OR [95% CI] = 1.57 [1.09, 2.25], p = 0.015) and rs146381257 (ZNF106; OR [95% CI] = 5.38 [1.07, 27.18], p = 0.042). Here, CHEK2 is linked to cancer.