BRCA2 and breast cancer: In our analyses of any 2+ primary cancers and our breast cancer-specific analysis, we replicated associations for known pleiotropic genes, BRCA2 (pLOF, p = 3.76 × 10−11 and 1.91 × 10−9) and CHEK2 (pLOF + missense, p = 2.95 × 10−11 and 1.67 × 10−8) (Fig. 3).