Whilst significant sex differences in the enrichment of gene expression related to GWAS loci were not observed between monocytes from men and women, F-MCs were enriched for the expression of IRM [31] (p = 0.002) and IFN-response gene sets [44] (p = 0.006) and for both AD1 [41] (p < 0.001) and AD2 [41] (p = 0.002) upregulated-genes; none of the IR-AD gene sets were significantly enriched in the M-MCs (Fig. 2C). This evidence concerns the gene MEG8 and Alzheimer disease.