In addition, several key molecules relevant to cell adhesion junctions and cytoskeleton remodeling pathways such as RhoA, RhoC, E-cadherin, and Vimentin were also examined in NPC cells after overexpression or knockdown of circPVT1, the results showed that circPVT1 could induce the expression of RhoA, RhoC, and Vimentin, whereas reduce E-cadherin expression (Fig. 6D). This evidence concerns the gene CDH1 and nasopharyngeal carcinoma.