CCM3-affected individuals tended to show a higher median total number of CCM (12.0 vs 7.0, P = 0.147) as well as a higher median number of CCM in the posterior fossa (2.4 vs 1.5, P = 0.980) and brainstem (1.0 vs 0.7, P = 0.800) in their first available brain MRI when compared with subjects with other known genotypes, although not statistically significant. This evidence concerns the gene PDCD10 and cerebral cavernous malformation.