Two reviews on the association between the inflammation process of IBD and the development of colorectal cancer have stressed the relation between certain cytokines such as IL-6, IL- α and TNF-α to NF-κB and proposed that its mechanism of action is related to its ability to block apoptosis by positively regulating the expression of anti-apoptosis proteins28,29. Here, NFKB1 is linked to inflammatory bowel disease.