SQSTM1 and neoplasm: Consistent with these data, pancreatic and liver tumours from Col Ir/r mice showed more-extensive expression of iCol I but no cCol I and lower levels of DDR1, p65, p62, NRF2, NHE1 and SDHB (a mitochondrial marker), as compared to tumours from Col IWT mice (Fig. 4e and Extended Data Fig. 5f,g).