RAP1A and cancer: Here we use RNAseq and KEGG pathway analysis to show that in HUVECs, IL-6 stimulation leads to the regulation of more than 11,000 genes (Fig. 6; Supplementary Data), many of which are involved in cytokine action, cancer and inflammatory pathways, including Rap1, PI3K, MAPK and JAK-STAT signalling (indicated by arrows in Fig. 6B).