For example, although glucose metabolism was not assessed, utilizing the Matsuzawa model, Dr. Harvey Lodish’s group found that APN KO mice weigh less, exhibit significantly less epididymal fat weight, and show dramatically less hepatic steatosis when challenged with a high-fat diet (HFD)13—all findings not described in the original publication utilizing this mouse model50. This evidence concerns the gene ANPEP and Hepatic steatosis.