Therefore the mAktDKO mice may represent a good model to elucidate the pathogenesis and mechanisms of sarcopenia, in which loss of mass and dys-function of skeletal muscle were induced and accelerated with aging, accompanied by insulin resistance and glucose intolerance, in contrast to the skeletal muscle-specific Akt1 or Akt2 single-knockout mice, which did not exhibit reduced body weight (Supplementary Fig. 3h, i). Here, AKT2 is linked to sarcopenia.