USP28 and neoplasm: Inhibition of USP28 is particularly effective in mouse LSCC models, resulting in dramatic tumor regression.258,265 The USP28 inhibitor used by Prieto-Garcia et al.258 was AZ1, a dual USP25/USP28 inhibitor, while the USP28 inhibitor FT206 used by Ruiz et al.,265 preferentially inhibits USP28 compared to USP25.