FBXW7 and neoplasm: FBXW7 is a typical tumor suppressor that targets many oncoproteins for ubiquitylation and degradation.261 FBXW7 dimerization is disrupted by the binding of FBXW7 and LSD1 which promotes FBXW7 self-ubiquitylation and degradation through proteasome and lysosomal pathways, independent of the demethylase activity of LSD1, thus leading to accelerated growth47 (Fig. 4c).