SOX2 and cancer: Given that SOX2 is amplified in various types of cancer and involved in tumorigenesis via complicated signaling pathways and protein–protein interactions, targeting SOX2 is a promising strategy for anticancer therapy.40 Previously, as a transcription factor, SOX2 was deemed undruggable because of its absence of active sites or allosteric regulatory pockets to be targeted by small molecule inhibitors (SMIs).244 Therefore, studies targeting SOX2 in anticancer therapy has been focusing on the upstream and downstream signaling of SOX2.