EZH2 and neoplasm: An important epigenetic modulator in LSCC is the H3K27 methyltransferase EZH2, whose dependency was observed in SOX2 amplified LSCC cell lines.38 Like other epigenetic modulators, EZH2 also plays an important role in mediating the immune response to the tumor both in tumor cells and immune cells (Fig. 6d).