CHRNA5 and atrial fibrillation: In addition, we also found evidence for associated aSNPs affecting the amino acid sequences two genes; SCML4 (rs117914882, chr6:108,076,801_T/C, ‘period of unenthusiasm/disinterest’, archaic AF < 1%) and CHRNA5 (rs76071148, chr15:78,885,574_T/A, ‘Cigarette consumption per day’, archaic AF = 27.8%, Table S3).