Correlation to classical HLA alleles associated to SSc on a genome-wide level was found to be small (r2 < 0.3) for most haplotypes with the exceptions of HLA-B*08:01 and HLA-C*07:01 which had a strong correlation (r2 = 0.82 and 0.67, respectively) with the BS haplotype and HLA-C*16:01 with AL-BS (H2111B) of 0.63 (Supplementary Dataset 1). The gene discussed is HLA-B; the disease is systemic sclerosis.