IGFL2 and neoplasm: Two tumor-originated clusters (Fib04, Fib09) showed distinctive enrichment in cell-cycle (e.g., STMN, PTTG) and TNFα signaling pathway (Fig. 7c–f), typically co-opting the wound healing-like programs of cellular proliferation and metabolic rewiring (e.g., IGFL2, TNC) (Fig. 7d)47.