Besides, MIF-EGFR/TNFRSF14, IGF1/2-IGF1R/2 R, TNFSF12-TNFRSF12A (TWEAK-Fn14) interactions also mediated the crosstalk between TPF or SLF with EPCs, consistent with their function in facilitating tumor progression (Supplementary Figs. S16, S17 and Table S6). This evidence concerns the gene IGF1 and neoplasm.