Moreover, expression of the PKM2 T45A mutant decreased cell proliferation, and overexpression of neither the WT nor KD Aurora A rescued the decrease of cell growth in the T45A mutant–expressing H1299 cells (Fig. 5B), illustrating that phosphorylation of PKM2 at T45 contributed to the protumor function of Aurora A. Similar results on tumor growth were also obtained in a H1299 xenograft mouse model (Fig. 5C). Here, PKM is linked to neoplasm.