HMGCS1 and type 2 diabetes mellitus: Specifically, the expression of, among others, lanosterol demethylase (CYP51A1), 7-dehydrocholesterol reductase (DHCR7), farnesyldiphosphate farnesyltransferase (FDFT1), farnesyl diphosphate synthase (FDPS), hydroxymethylglutaryl CoA synthase (HMGCS1), isopentenyl-diphosphate δ-isomerase 1 (IDI1), lanosterol synthase (LSS), diphosphomevalonate decarboxylase (MVD), mevalonate kinase (MVK), squalene monooxygenase (SQLE), and transmembrane 7 superfamily member 2 (TM7SF2) was increased 1- to 2-fold in liver of T2D compared with CTRL (Figure 5B).