,2 Besides genetic factors, various cellular components, such as proteins and metabolites, have been reported to be consistently altered in T2D, partly driven by environmental factors.3, 4, 5 Several studies have associated the effects of insufficient insulin with specific cellular deregulations, including glucose levels and lipid deposition in tissues and fatty acid uptake and metabolism.6, 7, 8. Here, INS is linked to type 2 diabetes mellitus.