Because these complicationsare associated with poor glycemic control, MG and MG-AGEs are proposedto be associated with and potentially drive them through RAGE-dependentmechanisms.267 The association of bothMG and MG-AGEs in diabetic complications such as nephropathy, cardiovascularproblems, cancer, and skeletomuscular disease have been extensivelycovered above. The gene discussed is AGER; the disease is cancer.