RAGE is an immunoglobulin transmembranepattern-recognition receptor that is expressed on a range of cells,including endothelial,115,116 immune,116,117 skeletal muscle,118 and cancer cells.119−121 RAGE is generally present in three primary forms, as a full-lengthmembrane-bound receptor (flRAGE), as a soluble product (sRAGE) createdby ADAM10-mediated cleavage of flRAGE, and as a splice variant knownas endogenous secretory RAGE (esRAGE).122 Binding of MG-AGEs to RAGE has been investigated both with freemodified amino acids and with modified proteins such as albumin. This evidence concerns the gene AGER and cancer.