NR1H4 and familial hypercholesterolemia: The fasting or postprandial total bile acid (BA) concentrations are increased after RYGBP and LOAGBP procedure, which is beneficial to weight loss, because of their action through farnesoid X receptor (FXR) and membrane Takeda G protein–coupled receptor 5 (TGR5) in the regulation of lipid accumulation and gluconeogenesis as FXR and TGR5 agonists decrease lipogenesis, improve hypercholesterolemia, increase energy consumption, and decrease systemic inflammation [30].