In the present study, we consistently showed that RAD51AP1 expression was markedly increased in the ESCC tissues from data in the TCGA database and high expression of RAD51AP1 was related to poor prognosis of ESCC patients, suggesting that RAD51AP1 might be a potential biomarker for the prognosis of ESCC. This evidence concerns the gene RAD51AP1 and esophageal squamous cell carcinoma.