DPP4 and type 2 diabetes mellitus: Given the key role of DPP4 in glucose metabolism through the regulation of circulating levels of insulinotropic incretins and considering that T2DM is a multifactorial disease with a clear genetic component (26), the present study aimed to verify the association of a haplotype constituted by two common SNPs (rs2268894 and rs6741949) in non-coding regions of the DPP4 gene with T2DM and fasting glycemia-related variables in a sample of Brazilian older adults, taking serum levels and enzymatic activity of DPP4 into account.