Of the several pharmacologic agents that have been used in SCAD patients (including aspirin, beta-blockers, calcium-channel blockers, ACE-inhibitors, and statins), only beta-blockers have been shown to reduce the risk of recurrent SCAD.[79] In 1 study,[1] statin use was higher in the SCAD recurrence group; however, the data analysis was limited. The gene discussed is ACE; the disease is spontaneous coronary artery dissection.