Activator protein-2 gamma (AP-2γ) belongs to the AP-2 family of transcription factors and consists of 5 discovered members: AP-2α AP-2β, AP-2γ, AP-2δ, and AP-2ε.[4] The amino acid sequences of AP-2α, AP-2β, and AP-2γ shared >75% similarity, whereas AP-2δ and AP-2ε exhibited more distinct features.[5–7] Furthermore, the regulatory roles of AP-2γ transcription factors in tumor progression have been extensively investigated in many cancer types. Here, TFAP2B is linked to cancer.