Particularly, the nuclear AP-2γ and Wwox expression levels even showed advantages over HER2 and PR in predicting resistance in low-risk and high-risk patients.[31] Considering that Wwox can inhibit AP-2γ from entering the nucleus by physically binding to AP-2γ,[32] these results may indicate that AP-2γ cell distribution mediated by Wwox also plays a crucial role in determining the tamoxifen response in breast cancer. This evidence concerns the gene ERBB2 and breast carcinoma.