At this stage, it is imperative to highlight that TIMP-3 protein accumulation is not only observed in SFD but also in other pathological conditions, including retinitis pigmentosa and AMD, where there is abnormal material deposition at the level of Bruch membrane.[3,40,43,46,47] Therefore, understanding the underlying pathophysiological mechanisms associated with TIMP-3 variants will shed more light into gaining more insight about SFD and other TIMP-3 associated retinopathies as well and will help devise treatment strategies in the future.[3]. Here, TIMP3 is linked to age-related macular degeneration.