In our study, the hub genes in the PPI network included CXCL8, TLR2, CXCL1, ICAM1, CXCR4, FPR2, SELL, PTEN, TREM1, and LEP, which play important roles in the occurrence and development of neutrophil-predominant severe asthma. Here, CXCR4 is linked to asthma.