This analytical strategy revealed that the important functions and pathways related to neutrophil-predominant severe asthma include the inflammatory response, neutrophil chemotaxis, and signaling pathways of MAPK cascade, JNK cascade, NF-κB, IL-8-mediated, cytokine–cytokine receptor interaction, MyD88-dependent TLR, NOD-like receptor, and NET formation. This evidence concerns the gene MAPK8 and asthma.