As summarized in previous studies, the survival of proinflammatory neutrophils is enhanced in children with neutrophil-predominant severe asthma, which is accompanied by increased neutrophil activation and airway release of proinflammatory cytokines and chemokines.[29] The proinflammatory cytokines IL-8 mediate the recruitment and activation of neutrophils and then enhance the migration of neutrophils into airways.[30] Eventually, this leads to increased inflammation of the lungs and severe asthma with airway remodeling.[31]. This evidence concerns the gene CXCL8 and asthma.