The results showed a significant correlation between the high expression of AFAP1-AS1 and OS in gastric cancer (HR = 1.84, 95% CI: 1.51–2.24, P < .001), colorectal cancer (HR = 1.91, 95% CI: 1.43–2.56, P < .001), PAAD (HR = 2.31, 95% CI: 1.64–3.26, P < .001), HCC (HR = 1.63, 95% CI: 1.24–2.15, P < .001), and other types of DSC (HR = 2.24, 95% CI: 1.73–2.90, P < .001; Figure 2). The gene discussed is AFAP1; the disease is colorectal cancer.