AFAP1 and esophageal adenocarcinoma: It belongs to the AFAP1, AFAP1 class-1, and AFAP1 like-2/xb-130 family.[50,51] Wu et al[52] was first to report that AFAP1-AS1 was overexpressed in Barrett esophagus and esophageal adenocarcinoma owing to its gene site hypomethylation.