It is involved in a variety of physiological functions and cancer behaviors, such as migration, invasion, metastasis, and angiogenesis.[6–9] In recent years, AFAP1-AS1 has been found to be abnormally expressed in many cancers, including cholangiocarcinoma, pancreatic adenocarcinoma, hepatocellular carcinoma,[6–8] colorectal cancer, gastric cancer, and esophageal cancer.[10–12]. This evidence concerns the gene AFAP1 and cancer.