High expression of AFAP1-AS1 was related to size (>5 cm; HR = 2.23, 95% CI: 1.57–3.16, P < .001), degree of differentiation (poor; HR = 1.42, 95% CI: 1.05–1.92, P = .02), stage (III, IV; HR = 2.88, 95% CI: 2.18–3.80, P < .001), lymph node metastasis (HR = 3.08, 95% CI: 2.18–4.34, P < .001), and high tumor-node-metastasis (TNM) stage (HR = 2.11, 95% CI: 1.18–3.77, P = .01). This evidence concerns the gene AFAP1 and metastatic malignant neoplasm in the lymph nodes.