CFTR and Infertility: A majority of CBAVD cases (80%) are related to CFTR mutations;however, the remaining (20%) possess no clear etiology.114 WES discoveryof the CFTR gene permitted the identification of adhesion G protein-coupledreceptor G2 (ADGRG2) on the X chromosome at locusp22.13.115ADGRG2 is part of a family of receptors throughout the body butspecifically appears to have a tissue-restricted pattern to the efferent ductswith gene deletion, providing a possible etiology of infertility in thesemen.114