86 Although both may cause infertility albeit withdifferential effects on semen quality, CATSPER1 isnon-syndromic, whereas CATSPER2 is syndromic(deafness-infertility syndrome).87 At a semen analysis level, menwith CATSPER1 mutations have oligozoospermia, reduced semenvolume, minor changes to sperm motility, and some effect on morphology, whereasmen with CATSPER2 mutations have oligozoospermia,asthenospermia, teratazoospermia, and reduced viability.87 Here, CATSPER1 is linked to Reduced sperm motility.