Two separate studies among the Spanish and Japanese populations showed an association between the PRM1 gene (c.-190C>A) and male infertility.17,20 A meta-analysis study that examined the correlation of 6 different SNPs (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, and rs2070923) with male infertility has also defined PRM1 c.-190C>A polymorphism (rs2301365) as a risk factor of male infertility, but no association is reported between the other studied SNPs and male sterility18 which is consistent with our results. This evidence concerns the gene PRM1 and male infertility.