The PRM2 c.248C>T (rs74007626) polymorphism that replaces glutamine amino acid codon with stop-codon is also reported benign among the Japanese and Iranian populations.17 In contrast with our findings, a meta-analysis study has reported a correlation between PRM2 rs1646022 polymorphism and an increased risk of male infertility.15 The difference in ethnicity, control source, sample size, and genotyping method may be the cause of contradictory results. The gene discussed is PRM2; the disease is male infertility.