PYGO2 and male infertility: Genetic diversity involved in this process may play an important role in spermatogenesis defects and male infertility.3,4Pygo2, DAZL, and PRM1 are some genes involved in spermatogenesis which are reported to play the main role in male infertility.5 Human PYGO2 protein is localized in the nucleus and composed of 2 domains: the zing finger motif (PHD) and the N-terminal homology domain (NHD).6PYGO2 acts as a co-activator of the Wnt pathway.