PRM2 and male infertility: This causes maximum compression of the chromatin to be placed in the sperm head.15Pygo2 gene is also essential for chromatin remodeling and regulate TNP2and PRM gene expression via histone methylation changes.11 In the present research, there was no association between studied SNPs of PRM genes (PRM2 rs1646022, PRM2rs11645592, PRM1rs737008, and PRM1rs423668) and male infertility among the Iranian population.