In addition to demonstrating that human cells in which ZMPSTE24 is knocked out, or its expression knocked down, are sensitized to SARS-CoV-2 pseudovirus infection (Fig. 2), we have also provided evidence that mouse Zmpste24−/− knockout fibroblasts are more sensitive than WT fibroblasts to a bona fide viral infection, using the mouse betacoronavirus MHV and assaying viral production by plaque assay as well as cell viability upon infection (Fig. 6). Here, ZMPSTE24 is linked to viral infectious disease.