Knockdown (KD) of ZMPSTE24 expression with siRNA resulted in increased infection by SARS-CoV-2 Spike-pseudotyped lentivirus compared to treatment with a control (scrambled) siRNA, as detected by immunofluorescence (Fig. 2B) and measured by the luciferase assay (Fig. 2C). Here, ZMPSTE24 is linked to infection.