p38 inhibitors were found to prevent expression of DUX4 from its native locus in both FSHD patient-derived myotubes and mouse xenograft models of FSHD, paving the road for clinical development (Oliva et al., 2019; Rojas et al., 2020). The gene discussed is MAPK14; the disease is facioscapulohumeral muscular dystrophy.