p38 inhibition has been shown to prevent DUX4 expression in FSHD patient-derived myotubes, thereby preventing cell death (Oliva et al., 2019; Rojas et al., 2020); however, a role in DUX4 mediated-apoptosis independent of DUX4 expression has not been explored. The gene discussed is DUX4; the disease is facioscapulohumeral muscular dystrophy.