MAPK8 and facioscapulohumeral muscular dystrophy: However, a recent study suggested that JNK is also involved in muscle degeneration in a cancer-associated cachexia mouse model and that JNK inhibition could prevent muscle wasting (Mulder et al., 2020), providing some hope that JNK inhibition could benefit people with FSHD if toxicity in muscle and other tissues can be avoided.