HAVCR2 and myelodysplastic syndrome: Upregulation of TIM-3 is also associated with leukemic transformation of pre-leukemic diseases, including myelodysplastic syndromes (MDS) and myeloproliferative neoplasms, such as chronic myelogenous leukemia [27], and TIM-3 expression on MDS blasts has also been found to correlate with disease progression[28].