Furthermore, utilizing the mouse clone, Liao CY et al. discovered that rapamycin administration leads to increased body weight and fat content, as well as longer longevity [56].Although the findings suggest that LMNA KO mice have a positive effect, this model does not replicate the eugenics and pathogenesis of HGPS in patients [57]. This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.