In HGPS patient fibroblasts and HGPS patient iPSC-derived mesenchymal stem cells (MSCs) and vascular smooth muscle cells (VSMCs), MG132 causes progerin nucleocytoplasmic translocation following transformation across the nucleolus and progerin removal by macro apoptosis (VSMCs) [66]. The gene discussed is LMNA; the disease is Hutchinson-Gilford progeria syndrome.