LMNA and progeroid syndrome: Certainly, Osorio FG et al. investigated the synergetic effect of administrating two AONs: "MmEx11," which targets the progeria mutation-activated exon 11 atypical splice section for the sake of preventing its usage, and "MmEx10," which targets the functional exon 10 splice section that aims in strengthening the initial AON's activity by shifting splicing events toward lamin C production [67].