According to Kreienkamp R et al., restoring VDR signaling with 1,25-dihydroxyvitamin D3 (1,25D), the active hormonal form of vitamin D, enhances HGPS symptoms such as DNA repair deficiencies, premature senescence, and nuclear morphological abnormalities [49]. The gene discussed is VDR; the disease is Hutchinson-Gilford progeria syndrome.