Russel and colleagues26 combined MUCIN-16, Vitamin K-dependent protein Z (PROZ), phosphatidylcholine-sterol acyltransferase (LCAT) and C-reactive protein (CRP) into a multiplex biomarker panel that, when used against a patient’s own baseline, displayed promise in detecting ovarian cancer 1–2 years earlier than current diagnostic methods. Here, PROZ is linked to ovarian cancer.