RYR1 and Alzheimer disease: In muscles from patients with AD-RYR1-related CCD DNMT3A expression levels were increased (the mean log2-fold change was 1.16 adjusted P = 0.03), whereas in AR RYR1-related MmD/CNM, HDAC4 expression levels were increased though they did not achieve statistical significance (the mean log2-fold change was 1.58 adjusted P = 0.06; Fig. 3F).