RYR1 and cancer: We chose to quantify the expression of myo-miRNAs, i.e. those that are specifically expressed in muscles including miRNA-1, -95, -133, -206 and -486,48 miRNAs that are predicted to bind to the 3′-UTR of the RYR1 (miRNA-22 and -124) and to bind to HDACs (epigenetic related), and miRNAs binding to transcripts whose products are involved in signalling (miRNA-19 and 221) and tumour suppression/proliferation (cancer related, miRNA-16).