MTM1 and centronuclear myopathy: Myotubularin de-phosphorylates phosphatidylinositol 3 monophosphate and phosphatidylinositol 3,5-bisphosphate, lipids playing a role in intracellular vesicle trafficking and autophagy.14 Interestingly, MTM1-related CNM is accompanied by an up-regulation of DNM2 and this negatively affects the structure and function of triads, suggesting that regulating DNM2 expression may be a potential target for therapeutic intervention.15,16