RYR1 and Alzheimer disease: Interestingly, the levels (fold change) of transcript encoding epigenetic enzymes were not impacted in muscles from patients with AD nemaline myopathy (Fig. 3G) and in AD-RYR1-related CCD only, the expression level of DNMT3A was increased (the mean log2-fold change was 1.16 adjusted P = 0.03; Fig. 3E).