Therefore, as this study suggests, a loss of astrocyte-mediated regulation is a major contributor to neuronal network pathophysiology in Alzheimer’s disease,71 and as total tau reduction beneficially suppresses aberrant neuronal network activities,6,15 it is feasible to postulate that the benefit of total tau ablation in vivo could arise in part from astrocytic tau downregulation. Here, MAPT is linked to Alzheimer disease.